The draw for the second round of the 2009 Australian Open is as follows.
| Australian Open – Second Round Draw – Top Half | |||||
| [1] Rafael Nadal (ESP) | vs | Roko Karanusic (CRO) | Third Round |
Fourth Round |
Quarter Finals |
| Tommy Haas (GER) | vs | Flavio Cipolla (ITA) | |||
| [24] Richard Gasquet (FRA) | vs | Denis Istomin (UZB) | Third Round |
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| Guillermo Canas (ARG) | vs | [13] Fernando Gonzalez (CHI) | |||
| [12] Gael Monfils (FRA) | vs | Stefan Koubek (AUT) | Third Round |
Fourth Round |
|
| Fabio Fognini (ITA) | vs | [17] Nicolas Almagro (ESP) | |||
| [25] Ivo Karlovic (CRO) | vs | Mario Ancic (CRO) | Third Round |
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| Chris Guccione (AUS) | vs | [6] Gilles Simon (FRA) | |||
| [4] Andy Murray (GBR) | vs | Marcel Granollers (ESP) | Third Round |
Fourth Round |
Quarter Finals |
| Andreas Beck (GER) | vs | [31] Jurgen Melzer (AUT) | |||
| [22] Radek Stepanek (CZE) | vs | Michael Berrer (GER) | Third Round |
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| Arnaud Clement (FRA) | vs | [14] Fernando Verdasco (ESP) | |||
| [9] James Blake (USA) | vs | Sebastien De Chaunac (FRA) | Third Round |
Fourth Round |
|
| Ernests Gulbis (LAT) | vs | [18] Igor Andreev (RUS) | |||
| Dudi Sela (ISR) | vs | Victor Hanescu (ROU) | Third Round |
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| Ivan Ljubicic (CRO) | vs | [5] Jo-Wilfried Tsonga (FRA) | |||
| Australian Open – Second Round Draw – Bottom Half | |||||
| [7] Andy Roddick (USA) | vs | Xavier Malisse (BEL) | Third Round |
Fourth Round |
Quarter Finals |
| Fabrice Santoro (FRA) | vs | [32] Philipp Kohlschreiber (GER) | |||
| [21] Tommy Robredo (ESP) | vs | Viktor Troicki (SRB) | Third Round |
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| Yen-Hsun Lu (TPE) | vs | [10] David Nalbandian (ARG) | |||
| [16] Robin Soderling (SWE) | vs | Marcos Baghdatis (CYP) | Third Round |
Fourth Round |
|
| Simone Bolelli (ITA) | vs | [23] Mardy Fish (USA) | |||
| [28] Paul-Henri Mathieu (FRA) | vs | Amer Delic ((L)) | Third Round |
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| Jeremy Chardy (FRA) | vs | [3] Novak Djokovic (SRB) | |||
| [8] Juan-Martin Del Potro (ARG) | vs | Florian Mayer (GER) | Third Round |
Fourth Round |
Quarter Finals |
| Bernard Tomic (AUS) | vs | Gilles Muller (LUX) | |||
| [19] Marin Cilic (CRO) | vs | Janko Tipsarevic (SRB) | Third Round |
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| Dominik Hrbaty (SVK) | vs | [11] David Ferrer (ESP) | |||
| [15] Stanislas Wawrinka (SUI) | vs | Brydan Klein (AUS) | Third Round |
Fourth Round |
|
| Brian Dabul (ARG) | vs | [20] Tomas Berdych (CZE) | |||
| [26] Marat Safin (RUS) | vs | Guillermo Garcia-Lopez (ESP) | Third Round |
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| Evgeny Korolev (RUS) | vs | [2] Roger Federer (SUI) | |||